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All of the active B12 group reporting showed reduction in severity of symptoms ranging from hair 31% to 70%, while the placebo controls reported either no change or a worsening of symptoms. Wilcoxon-Rank of .002 for the end-points of sneezing, nasal congestion and runny nose; and p = .005 removal for IgE reductions. In 1992, stone the above mentioned data from 1988 on were presented by Dr. O''Connor to the FDA. The FDA panel acknowledged the safety of the treatment. The panel seemed to products be in agreement that the statistics indicated a significant reduction in IgE and that a quantitative drop in symptoms was demonstrated. In 1992, Belen Anibarro, MD, studied five children with hair asthma with metabisulfite intolerance confirmed removal by oral challenge testing. The test was repeated after premedication with 1.5 mg of oral stone cyanocobalamin. In four of the five patients treated, bronchospasm did not develop in the second metabisulfite challenge.6

Studies indicate that ingested oral cyanocobalamin tablets are ineffective in the treatment of allergic disease, products perhaps because once ingested, they are directly metabolized in the liver. When B12 is delivered via injection or lozenge it passes throughout hair the bloodstream before arriving at the liver. It is during this first pass in its native form that it is believed to exert removal its therapeutic effect. CLINICAL stone and products RESEARCH: "The World Health Organization hair (WHO) removal recognizes allergic rhinitis (hay fever), sinusitis, asthma,...conjunctivitis, urticaria, stone eczema, dermatitis (contact and atopic)...allergic products and migraine headache...as diseases in which IgE-mediated allergy may be involved."1 In 1988, asthma and allergic rhinitis subjects were treated with B12. hair Total IgE, specific IgE and pulmonary removal lung functions were taken at days 45, 150 and 180 from baseline. stone Eight of the 9 subjects products had reduced IgE. 2 In 1989 open label studies at two sites in Riverside County, CA in 1989. Sixteen of the 17 subjects had lowered IgE levels from Day 0 to Day 30.3